Epithalamin. Can it extend life?

Black and white cut-away drawing of the brain with the epithalamus highlighted in red positioned in the center of the brain.

Epithalamin, also known as epitalon, epithalon and epithalamine, is a pineal gland peptide preparation that has been proven to extend the healthspan of elderly people, particularly those with advanced cardiovascular disease. One study in Russia followed elderly patients with cardiovascular disease over a 12 year period, treating them with epithalamin, and the control group with a placebo.The results of this study demonstrated a 28% decrease in overall mortality with those treated with epithalamin, and a 2-fold decrease in cardiovascular mortality by decreasing the functional age and degree of cardiovascular aging. Another study showed that by adding Thymalin with Epithalamin those treated over a 6 year period had a mortality rate that was 4.1 times lower than the control group.[1][2]

The study of epithalamin and therapies using this and other peptide bioregulators were pioneered by Vladimir Khavinson, holder of 196 patents and author of 775 scientific publications. He called this class of peptides geroprotectors.[3] His research on these peptides showed promising results with no toxic, allergic or adverse effects. In short, this chemical increases life expectancy.

This string of four amino acids got its name from the region of the brain where it’s found, the epithalamus. It is isolated from the epithlamium-epiphyseal region of the brain, which is basically right in the center of the brain, just above the pituitary gland. It’s job is to normalize the function of the anterior pituitary gland and levels of melatonin in the blood. Medically it is used for the treatment of menopausal disorders, myocardiodystrophy, a type of non-inflammatory heart disease that affects the muscles of the heart, and endometrial hyperplasia, an abnormal growth of cells in the lining of the uterus. Important to our search for longevity is the fact that it appears to simulate a pineal gland chemical that activates the production of telomerase, promoting the repair and lengthening of DNA telomeres (See Telomeres).


A synthetic version of epithalamin known a Epithalon is available over the counter (http://awakebrain.com/epithalon/). The compound is mixed with sterile distilled water or nasal saline spray and administered by spraying it into the nostrils. Normally the suggested dose is 6 mg a day for the first 10 to 30 days, switching to a maintenance dose of 2 to 3 mg a day.

Just a note, I am not a doctor nor am I promoting or suggesting course of medical therapy.

Anti-aging compounds currently target the age-related decline of important cellular chemicals and the number of telomeres capping our chromosomes. Epithalamin appears to do both. You will pay about two to four times the price of most oral health supplements, about $80 a month, and it’s taken nasally. Many years of research, primarily in Russia where laws about using human subjects is a bit more lax, has shown that epithalamin has increased both the health and lifespan of both lab animals and humans.


  1. Bull Exp Biol Med. 2006 Sep;142(3):356-9, Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging., Korkushko OV1, Khavinson VKh, Shatilo VB, Antonyuk-Shcheglova IA.
  2. Neuro Endocrinol Lett. 2003 Jun-Aug;24(3-4):233-40.,Peptides of pineal gland and thymus prolong human life.,Khavinson VKh1, Morozov VG.
  3. https://en.wikipedia.org/wiki/Vladimir_Khavinson
  4. Bulletin of Experimental Biology and Medicine,June 2003, Volume 135, Issue 6, pp 590-592, Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells, V. Kh. Khavinson , I. E. Bondarev, A. A. Butyugov

Posted by Ted Coombs

Ted Coombs
Ted Coombs is a medical anthropologist, futurist and author who is passionate about health through knowledge.